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Combination of Transcranial Electro-Acupuncture and Fermented Scutellaria baicalensis Ameliorates Motor Recovery and Cortical Neural Excitability Following Focal Stroke in Rats
경두개 전침과 발효황금 병행 투여가 흰쥐의 허혈성 뇌세포 손상에 미치는 효과
Korean J Acupunct 2018;35:187-202
Published online December 27, 2018;  https://doi.org/10.14406/acu.2018.034
© 2018 Society for Meridian and Acupoint.

Min Sun Kim1,2 , Ho Koo1,2 , Myung Ae Choi1,2 , Se Jin Moon1,2 , Seung Bum Yang3 , Jae-Hyo Kim4,5
김민선1,2, 구호1,2, 최명애1,2, 문세진1,2, 양승범3, 김재효4,5

1Department of Physiology, Wonkwang University School of Medicine, 2Brain Science Institute at Wonkwang University, 3Department of Medical Non-commissioned Officer, Wonkwang Health Science University, 4Department of Meridian & Acupoint, College of Korean Medicine, Wonkwang University, 5Research Center of Traditional Korean Medicine, Wonkwang University
1원광대학교 의과대학 생리학교실, 2원광대학교 뇌과학연구소, 3원광보건대학교 의무부사관과, 4원광대학교 한의과대학 경혈학교실, 5원광대학교 한국전통의학연구소
Correspondence to: Jae-Hyo Kim
Department of Meridian & Acupoint, College of Korean Medicine, Wonkwang University, 460 Iksan-daero, Iksan 54538, Korea
Tel: +82-63-850-6446, Fax: +82-63-857-6458, E-mail: medicdog@wku.ac.kr
Received November 23, 2018; Revised December 5, 2018; Accepted December 6, 2018.
This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objectives : Non-invasive transcranial electrical stimulation is one of therapeutic interventions to change in neural excitability of the cortex. Transcranial electro-acupuncture (TEA) can modulate brain functions through changes in cortical excitability as a model of non-invasive transcranial electrical stimulation. Some composites of fermented Scutellaria baicalenis (FSB) can activate intercellular signaling pathways for activation of brain-derived neurotrophic factor that is critical for formation of neural plasticity in stroke patients. This study was aimed at evaluation of combinatory treatment of TEA and FSB on behavior recovery and cortical neural excitability in rodent focal stroke model. 
Methods : Focal ischemic stroke was induced by photothrombotic injury to the motor cortex of adult rats. Application of TEA with 20 Hz and 200 μA in combination with daily oral treatment of FBS was given to stroke animals for 3 weeks. Motor recovery was evaluated by rotating bean test and ladder working test. Electrical activity of cortical pyramidal neurons of stroke model was evaluated by using multi-channel extracellular recording technique and thallium autometallography. 
Results : Compared with control stroke group who did not receive any treatment, Combination of TEA and FSB treatment resulted in more rapid recovery of forelimb movement following focal stroke. This combination treatment also elicited increase in spontaneous firing rate of putative pyramidal neurons. Furthermore expression of metabolic marker for neural excitability was upregulated in peri-infract area under thallium autometallography.
Conclusions : These results suggest that combination treatment of TEA and FSB can be a possible remedy for motor recovery in focal stroke.
Keywords: ocal stroke, fermented Scutellaria baicalensis, transcranial electro-acupuncture, pyramidal neurons, neural excitability, thallium autometallography


December 2018, 35 (4)
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