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Thirteen Weeks Repeated-dose Toxicity Study on Aconitum ciliare Decaisne Pharmacopuncture Solution in Mice
초오 약침액의 13주 반복 시술 독성에 관한 연구
Korean J Acupunct 2018;35:139-148
Published online September 27, 2018;  https://doi.org/10.14406/acu.2018.022
© 2018 Society for Meridian and Acupoint.

Sung Chul Lim1 , Jae Soo Kim1 , Bong Hyo Lee1 , Hyun Jong Lee1 , Hyun Lee2 , Yun Kyu Lee1
임성철1, 김재수1, 이봉효1, 이현종1, 이현2, 이윤규1

1Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, 2Departmnet of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Daejeon University
1대구한의대학교 한의과대학 침구경혈학교실, 2대전대학교 한의과대학 침구의학교실
Correspondence to: Yun Kyu Lee
Deprtment of Acupuncture & Moxibution Medicine, Pohang Korean Medicine Hospital of Daegu Haany University, 411 Saecheonnyeon-daero, Nam-gu, Pohang 37685, Korea
Tel: +82-54-271-8010, Fax: +82-54-281-7464, E-mail: hanyeesarang@hanmail.net
Received August 27, 2018; Revised September 18, 2018; Accepted September 19, 2018.
This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objectives : This study was performed to examine the toxicity on the long term procedure of Aconitum ciliare Decaisne pharmacopuncture(ADP) solution.
Methods : To evaluate the long term toxicity of 3 different repeated doses, 60, 150, and 300 mg/kg/day for 13 weeks were injected into BALB/c mice, respectively. The ADP solution was injected into near ST36 of the right leg and normal saline of the same volume was used for the vehicle control group. To evaluate the toxicity of 60, 150, and 300 mg/kg of repeated doses for 13 weeks, toxic symptoms, weight measurement, hematological test, blood biochemical test, visual examination and weight measurement of major organs, and histopathological test were conducted.
Results : No significant changes in toxic symptoms, weight measurement, hematological test, blood biochemical test, visual examination and weight measurement of major organs, and histopathological test were observed in different doses of ADP solution treated groups compared to vehicle control group.
Conclusions : As a result, repeated dose at a concentration of 300 mg/kg or less is considered to be not harmful for clinical treatment.
Keywords: Aconitum ciliare Decaisne, pharmacopuncture, toxicity, repeated dose


September 2018, 35 (3)
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