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Effect of Radix Glycyrrhizae on the Melanogenesis of Melanoma Cell Line
멜라닌 합성 및 기전에 미치는 甘草의 효과
Korean J Acupunct 2001;18:101-111
Published online December 27, 2001
© 2001 Society for Meridian and Acupoint.

Ji-Sun Park1, Rae-Kil Park1, Jeong-Jung Kim2, Whang-Hee Lee3, Jong-Kook Lim4, Seung-IL Jeong5, Kyung-Sang Na6, Jong-Hyun Han6, Byung-Hun Jeon6
박지선1, 박래길1, 김정중2, 이황희3, 임종국4, 정승일5, 나경상6, 한종현6, 전병훈6
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
To investigate whether glycyrrhizae inhibits melanogenesis, we utilized B16 melanoma cells.
Glycyrrhizae alone decreased the tyrosinase promoter activity of B16 melanoma cells in dose-dependent
manner. Glycyrrhizae attenuated tyrosinase promoter activity and tyrosinase activity. Glycyrrhizae also
prevents phosphotransferase activity of c-Jun N-termianl kinase(JNK1) and transcriptional activation of
AP-1 in α-MSH-treated B16 melanoma cells. In conclusion, the current studies for the first time
demonstrated that an inhibitory effect of melanogenesis by glycyrrhizae on B16 mouse melanoma cell
might be a new mechanism which down-regulates JNK activity via inhibition of AP-1 activity.
Keywords: Glycyrrhizae, Melanogenesis, α-MSH, JNK1, AP-1

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