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Summary of animal experiments for acupoint treatment of focused ultrasound
| First author (year) | Study design/sample size (analysis) | Target disease | Experimental group (medium; acupoint or location; irradiation time; power density or total power) | Control gruop (medium; acupoint or location; irradiation time; power density or total power) | Main outcomes | Results | Adverse events |
|---|---|---|---|---|---|---|---|
| Liao (2011)14) | RCT/96 (96) | Hypoxic ischemic brain damaged rats | (A) FUS; GV20; once a day for 1 min until put to death; 10.20 MHz, 1,000 Hz | (B) Sham operation (nothing) (C) Model (nothing) (D) Acupuncture; GV20; 10 min; - |
1) Forelimb muscle strength 2) GAP-43 |
1)Suspension (7, 14, 21 d) (A) 13.7±3.1/36.7±7.4/52.0±9.0 (B) 18.0±2.7/79.0±14.0/101.3±20.0 (C) 7.6±1.8/18.9±.2/35.5±11.0 (D) 12.9±2.8/42.7±11.1/58.3±19.4 ․ Significant improvment in (A), (D) 2-1) GAP-43 mRNA (7, 14, 21 d) (A) 1.295±0.20/1.042±0.20/0.730±0.11 (B) 0.374±0.09/0.358±0.08/0.34±0.06 (C) 1.087±0.1/0.775±0.14/0.543±0.09 (D) 1.364±0.27/1.021±0.18/0.728±0.08 ․ Significant upregulated the expression in (A), (D) 2-2) GAP-43 protein (7, 14, 21 d) (A) 0.330±0.04/0.292±0.03/0.255±0.03 (B) 0.205±0.03/0.207±0.03/0.199±0.02 (C) 0.287±0.04/0.251±0.02/0.226±0.02 (D) 0.342±0.05/0.310±0.05/0.260±0.03 ․ Significant upregulated the expression in (A), (D) |
NM |
| Hu (2011)15) | RCT/196 (196) | Hypoxic ischemic brain damaged rats | (A) HIFU; GV20; 1 min; 10.20 MHz, 1,000 Hz, 0.5 W | (B) Sham (C) HIBD model (D) Acupuncture; GV20; 10 min; - |
Synaptophysin in hippocampus | 1) After 7/14/21d (A) 0.904±0.134/0.998±0.252/1.60±0.096 (B) 0.578±0.088/0.621±0.064/0.651±0.094 (C) 0.706±0.138/0.739±0.078/0.782±0.066 (D) 0.901±0.107/0.999±0.155/1.543±0.081 ․ Significant upregulated the expression in (A), (D) |
NM |
| Chen (2009)16) | RCT/40 (40) | Hyperlipemia rats | (A) Nothing (B) FUS; Kl1; 10 sec for 2 weeks; 15 W/cm2 (C) FUS; Kl1; 10 s for 2 weeks; 7.5 W/cm2 (D) Acupuncture; Kl1; 10 sec for 2 weeks |
(E) Nothing (no hyperlipemia rats) | 1) TC 2) TG 3) HDL-C 4) LDL-C |
TC/TG/HDL-C/LDL-C (A) 3.48±0.81/3.11±0.18/0.93±0.12/1.12±0.16 (B) 2.55±0.55/1.31±0.23/1.91±0.87/0.54±0.17 (C) 2.32±0.62/1.25±0.12/1.01±0.17/0.75±0.17 (D) 2.78±0.42/1.24±0.21/0.88±0.15/1.33±0.14 (E) 1.71±0.12/1.67±0.31/1.25±0.31/0.14±0.10 ․ TC and TG showed significant decrease in (B), (C) ․ HDL-C showed significant increase in (B) |
NM |
| Zhao (2011)17) | RCT/30 (30) | Healthy rabbit | FUS; ST36; 5 min; 2 W | Placebo group (no dosage) | 1) Electronic Von Frey 2) Biopsy |
Exp (right): 45.28±6.19→83.75±33.43 ( Exp (left): 44.65±5.78→80.9±28.98 ( Con (right): 44.60±5.6→46.26±6.71 ( Con (left): 144.57±5.01→46.49±6.52 ( |
No AE |
| Shao (2001)18) | RCT/16 (16) | Male rabbits | FUS; ST36; 5 min; 10∼20 W/cm2 |
Acupuncture; ST 36; 5 min; - | 1) Gastroscopy 2) Gastric electrometry |
Frequency/Amplitude Exp: 3.47±0.54→3.09±0.69 ( Con: 3.63±0.50→3.60±0.53 ( ․ No significant difference |
NM |
| Lin (2011)19) | RCT/30 (30) | Healthy rabbit | FUS; ST36; 5 min; 0.5 MHz, 2 W | Nothing | Electronic Von Frey | Only FUS group statistically different from baseline pain threshold. The pain threshold reached a maximum at 6 min, and then decreased slowly until 16 min it returned to the normal level. | NM |
sec : second, min : minute, FUS : focused ultrasound, Con : control group, Exp : experimental group, AE : adverse event, NM : not mentioned, TC : total cholesterol, TG : triglyceride, HDL-C : high density lipoprotein cholesterol, LDL-C : low density lipoprotein cholesterol.