Korean Journal of Acupuncture

Table. 5.

Table. 5.

Historical control data

Historical control values of micro nucleated polychromatic erythrocytes (MNPCE)

Group Hours after dosing (hr) Dose (mg/kg) N MNPCE/PCE (%)
(Mean±S.D.)
Range [MNPCE/PCE] (%) 95% control limit3) [MNPCE/PCE]
MIN MAX

Negative control 24 0 7 0.04±0.02 0 0.084* <13
Positive control 24 20 5 4.18±1.26 3.530* 4.835* -

Historical control values of ratio of polychromatic erythrocytes (PCE) to total erythrocytes

Group Hours after dosing (hr) Dose (mg/kg) N PCE/(NCE+PCE) (%)
(Mean±S.D.)
Range [PCE/(NCE+PCE)] (%)
MIN MAX

Negative control 24 0 7 34.2±4.37 30.6* 37.8*
Positive control 24 20 5 30.3±3.90 26.5* 34.1*

Negative control : Water for injection, Phosphrate buffered solution, 0.5% methyl cellulose 1500 centipoise solution, etc., Positive control : Cyclophosphamide (20 mg/kg, P.O., single dosing), N : The total number of micronucleus test, - : No data. The above historical control values were obtained fromn the data pooled from Feb. 26, 2016 to Apr. 24, 2020. *The range was calculated by the control limit of X derived from X-R value. a) Poisson-based 95% control limits of the historical negative control data.

Korean J Acupunct 2022;39:54-62 https://doi.org/10.14406/acu.2022.008
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