Korean Journal of Acupuncture

Table. 4.

Table. 4.

The ratio of polychromatic erythrocytes (PCE) to total erythrocytes in male mice in vivo micronucleus test

Group Dose (ml/animal) Route Hours after dosing (hr) PCE (PCE+NCE) MNPCE/PCE
Negative control Normal saline 0 I.M. 24 Total 782/2,500 10/20,000
% (Mean±S.D.) 31.3±0.90 0.050±0.018
Test substance SUEP 0.25 I.M. 24 Total 782/2,500 10/20,000
% (Mean±S.D.) 31.3±0.88 0.050±0.018
0.5 I.M. 24 Total 803/2,500 9/20,000
% (Mean±S.D.) 32.1±0.41 0.045±0.033
1.0 I.M. 24 Total 795/2,500 13/20,000
% (Mean±S.D.) 31.8±1.38 0.065±0.014
Positive control* CPA 20 mg/kg P.O. 24 Total 795/2,500 852††/20,000
% (Mean±S.D.) 31.8±1.24 4.260±0.060

I.M. : Intramuscular, P.O. : Per Os. (by mouth), SUEP : SU-Eohyeol pharmacopuncture agent with 9 herbs such as Cervi Parvum Cornu (50 mg/ml), Gardeniae Fructus (75 mg/ml), Olibanum (30 mg/ml), Myrrha (30 mg/ml), Corydalis Tuber (30 mg/ml), Persicae Semen (22.5 mg/ml), Salviae Miltiorrhizae Rrdix (22.5 mg/ml), Paeoniae Radix (22.5 mg/ml), and Sappan Lignum (22.5 mg/ml), CPA : Cyclophosphamide, MNPCE : Micro nucleated polychromatic erythrocytes, PCE : Polychromatic erythrocytes, NCE : Nomochromatic erythrocytes, MMC : mitomycin C, S.D. : Standard Deviation. *The positive control substance was administered once at 24 hours prior to sampling time. Significanct difference from negative control by Mann-Whitney U test: ††p<0.01.

Korean J Acupunct 2022;39:54-62 https://doi.org/10.14406/acu.2022.008
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