Korean Journal of Acupuncture

Table. 3.

Table. 3.

Changes in body weight of Male Sprague-Dawley Rats in the in vivo micronucleus test

Group Dose
(ml/animal)
Route Days after dosing (g)

before 1st dosing 1 day after 2nd dosing
Negative Control Normal Saline 0 I.M. 261.8±4.24 276.0±7.05
Test substance SUEP 0.25 I.M. 262.3±3.44 277.6±5.86
0.5 I.M. 260.8±8.85 273.0±10.2
1.0 I.M. 261.7±6.51 273.1±10.9
Positive Control* CPA 20 mg/kg P.O. 261.8±9.90 269.4±12.3

Data are presented as mean±S.D. (standard deviation). I.M. : Intramuscular, P.O. : Per Os. (by mouth), SUEP: SU-Eohyeol pharmacopuncture agent with 9 herbs such as Cervi Parvum Cornu (50 mg/ml), Gardeniae Fructus (75 mg/ml), Olibanum (30 mg/ml), Myrrha (30 mg/ml), Corydalis Tuber (30 mg/ml), Persicae Semen (22.5 mg/ml), Salviae Miltiorrhizae Rrdix (22.5 mg/ml), Paeoniae Radix (22.5 mg/ml), and Sappan Lignum (22.5 mg/ml), CPA: Cyclophosphamide. *The positive control substance was administered once at 24 hours prior to sampling time.

Korean J Acupunct 2022;39:54-62 https://doi.org/10.14406/acu.2022.008
© 2022 Korean J Acupunct