Korean Journal of Acupuncture

Table. 2.

Table. 2.

Clinical signs of main study in male Sprague-Dawley Rats

Group Dose
(ml/animal)
Route Animal ID Clinical Signs

1st dosing 2nd dosing 1 day after 2nd dosing

before
dosing
immediately after dosing before
dosing
immediately after dosing
Negative Control Normal Saline 0 I.M. 1101 - - - - -
1102 - - - - -
1103 - - - - -
1104 - - - - -
1105 - - - - -
Test
substance
SUEP 0.25 I.M. 1201 - - - - -
1202 - - - - -
1203 - - - - -
1204 - - - - -
1205 - - - - -
0.5 I.M. 1301 - - - - -
1302 - - - - -
1303 - - - - -
1304 - - - - -
1305 - - - - -
1.0 I.M. 1401 - - - - -
1402 - - - - -
1403 - - - - -
1404 - - - - -
1405 - - - - -
Positive Control* CPA 20 mg/kg P.O. 1501 - - - - -
1502 - - - - -
1503 - - - - -
1504 - - - - -
1505 - - - - -

I.M. : Intramuscular, P.O. : Per Os. (by mouth), SUEP: SU-Eohyeol pharmacopuncture agent with 9 herbs such as Cervi Parvum Cornu (50 mg/ml), Gardeniae Fructus (75 mg/ml), Olibanum (30 mg/ml), Myrrha (30 mg/ml), Corydalis Tuber(30 mg/ml), Persicae Semen (22.5 mg/ml), Salviae Miltiorrhizae Rrdix (22.5 mg/ml), Paeoniae Radix (22.5 mg/ml), and Sappan Lignum (22.5 mg/ml), CPA: Cyclophosphamide, -: No observavle abnormality. *The positive control substance was administered once at 24 hours prior to sampling time.

Korean J Acupunct 2022;39:54-62 https://doi.org/10.14406/acu.2022.008
© 2022 Korean J Acupunct