Korean Journal of Acupuncture

Table. 2.

Table. 2.

Treatments and outcomes of the included studies in animal model

No Study Treatment Outcome



Author Year Acupoints Catgut embedding size Treatment period Measurement Result


Needle Catgut Behavior test or morphological study Mechanical checker
1 Cui14) 2018 ST36, GB30 Diameter 0.7 mm 0.5 cm Once a week or every 4 days 1. Von Frey
2. Radiant heat
3. Gait analysis
4. Western blot
5. IHC staining
1. PWT ↑
2. PWL ↑
1. 5-HT1AR ↓
2. GluN1↓
3. CaMKII, ERK, CREB↓
2 Du15) 2017 BL60, ST36, SP6 None 1 cm None 1. Von Frey
2. Volume meter
3. Western blot
4. IHC staining
1. PWT ↑
2. Paw volume ↓
1. Sig-1R ↓
2. Sig-1R expression ↓
3. p38 mark ↓
4. ERK1/2 ↓
3 Li16) 2017 GB34, BL60 No.6 0.5 cm None 1. Radiant heat
2. Mircodialysis
3. HPLC-UV
TWL↑ 1. 5-HT ↓
2. HA↓
3. PGE2 ↓
4 Ma17) 2017 ST36, BL23 No.9 0.8 cm Once 14 days, total 42 days 1. IHC staining
2. ELISA
None 1. MVD ↓
2. IL-1, TNF-α ↓
5 Li18) 2016 ST36, BL60 No.6 0.5 cm Once 6 days, total 2 times 1. Electrical mechanical analgesia tester
2. Radiant heat
3. ELISA
1. TWL↑
2. MWT↑
IL-1, TNF-α ↓
6 Ma19) 2016 ST36, BL23, SP6, CV4 No.9 0.8 cm Once 14 days, total 42 days 1. HE staining
2. ELISA
AI ↓ 1. IL-17, IL-6 ↑
2. TNF-β1↑
3. Synovial hyperplasia, Inflammation, Angiogenesis change
7 Li20) 2015 Main: GV4, BL23, BL18, BL20, ST36 Assist: GB30, BL40, SP6 None 0.3∼0.7 cm (No.00) Once 9 days, total 27 days 1. ELISA
2. RAST
None IL-1, IL-2, TNF-α ↓
8 Fu21) 2012 ST36, BL23 None None Once 14 days, total 28 days 1. Flow cytometer
2. IHC staining
None 1. Fas (OD%) ↓
2. FasL (OD%) ↓
3. Bcl-2 (OD%)↑
4. Fas (positive rate) ↑
5. FasL (positive rate) ↑
6. Bcl-2 (positive rate) ↓
7. T-cell ↑
9 Fu22) 2010 ST36, BL23 No.9 0.8 cm Once 14 days, total 28 days 1. HE staining
2. IHC staining
3. Biomias99
None 1. MMP-2 ↑
2. MMP-9 ↑
10 Wang23) 2005 ST36, BL23 No.7 3-0# None RAST None 1. IL-2 ↑
2. Peripheral blood substance-P, Posterior horn of spinal cord substance-P↑
3. TNF-α ↓

AI : Arthritis index, ELISA : Enzyme-linked immunosorbent assay, HE : Hematoxylin & eosin, IHC : Immunohistochemistry, MWT : Mechanical withdrawal threshold, PWT : Paw withdrawal threshold, PWL : Paw withdrawal latency, RAST : Radio allegro sorbent test, TWL : Thermal withdrawal latency,

Korean J Acupunct 2021;38:122-32 https://doi.org/10.14406/acu.2021.020
© 2021 Korean J Acupunct