Korean Journal of Acupuncture

Table. 4.

Table. 4.

Treatment types in painand depression comorbid models

Types of treatment Treatment References
Depression-like behavior observed in pain model Drug Agonist ACEA, GW405833, Tramadol, Clonidine hydrochloride, 8-OH-DPAR, WIN55212, HU210, Sigma-1 receptor (σ1R) 29, 40, 55, 62, 82, 128
Antagonist ZD7288 (HCN channel) 79
Inhibitor ProTx-II, AG490, 1-MT, PcTx1, Manbalgin-1, SB242084, Ketamine, MPEP, Ro 61-8048, IL-1RA 18, 20, 21, 24, 110, 124, 132, 136
Antidepressant SSRI (Fluvoxamine, Fluoxetine, Vortioxetine), SNRI (Duloxetine), Amitriptyline, Desipramine 28, 47, 55, 61, 62, 99, 105, 137
Anesthetic Sevoflurane, Propofol, Pentobarbital sodium 59
Tranquilizer Diazepam, L-TAMS 25, 83, 104
Analgesic Pregabalin, Morphine, Cebranopadol 83, 115, 121, 133
H2S donors Allyl isothiocyanate, Isoliquiritin, Phenyl isothiocyanate 10, 86
Others Tat-fusion peptides, Ibuprofen, Minocycline, Riluzole, SAM, DUQ00021, Triptolide, 4-methylcatechol, Ethosuximide 51, 73, 89, 99, 100, 105, 123, 126, 138
Extract Sphaerococcus coronopifolius 135
Natural substance- derived chemicals Curcumin, Glycyrrhizic acid, dihydromyricetin, β-caryophyllene, isorhynchophylline, PSAP (α-(phenylselanyl) acetophenone), CMI, (m-CF3-PhSe)2, Chrysin, Sulforaphane, D-Aspartate 14, 17, 33, 43, 52, 59, 60, 81, 91, 93, 94, 97, 121, 131
Electroacupuncture ST36 65, 130
Cells injection CD3+T cells 41
Pain-like behavior observed in depression model Drug Inhibitor Rolipram 129
Antidepressant SSRI (Fluoxetine, citalopram), Imipramine, Desipramine 23, 27, 53, 54, 129
Antianxiety Buspirone 27
Tranquilizer Diazepam 53, 129
Analgesic Morphine 27
Natural substance- derived chemicals α-(phenylselanyl) acetophenone, trans-Resveratrol 129
Herbal medicine Withania somnifera 34
Pain and depression comorbidity model Drug Agonist 6-chloromelatonin, Pramiexole 35, 75
Antagonist SB-366791 (TRPV1), 5-BDBD (P2X4), IL-1 receptor antagonist, 2-BFI, Phenyzoline 49, 68, 90, 143
Inhibitor Metyrapone 120
Antidepressant SSRI (Fluoxetine), SNRI (Duloxetine) 54, 62
Analgesic CR4056, 3,5-Dimethyl-1-phenyl-1H-pyrazole 106
Anti-inflammatory Diclofenac 118
Natural substance- derived chemicals Curcumin, Palmatine, Omega-3 polyunsaturated fatty acid, Gentiopicroside, Osthole, skimmetin, α-Spinasterol, p,p'-Methoxyl-diphenyl diselenide, ferulic acid, α-(phenylselanyl) acetophenone 22, 31, 50, 64, 70, 76, 90, 109, 118
Electroacupuncture ST36, SP6 15, 67

ACEA : arachidonyl-2-chloroethylamide, AG490 : 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide, 5-BDBD : 5-(3-Bromophenyl)- 1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, 2-BFI : 2-(2-benzofuranyl)-4,5-dihydro-1H-imidazole hydrochloride, CR4056 : 6-imidazol-1-yl-2-phenylquinazoline, CMI : 3-(4-Chlorophenylselanyl)-1-methyl-1H-indole, DUQ00021 : fraction of HPLC with affinity for the 5-HT7R, GW405833 : cannabinoid receptor 2 (CB2) agonist, HU210 : 1,1-dimethylheptyl-11-hydroxytetrahydrocannabinol, IL-1RA : interleukin-1 receptor antagonist, MPEP : 2-Methyl-6-(phenylethynyl)pyridine hydrochloride, 1-MT : 1-methyl-tryptophan, PcTx1 : psalmotoxin, Ro 61-8048 : 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide, SAM : S-adenosylmethionine, SB242084 : 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide dihydrochloride hydrate, SB-366791 : 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide, SNRI : serotonin–norepinephrine reuptake inhibitors, SSRI : selective serotonin reuptake inhibitor, ST36 : Zusanli, SP6 : Sanyinjiao, L-TAMS : L-threonic acid magnesium salt, WIN55212 : WIN-a non-selective cannabinoid CB1 and CB2 receptor agonist.

Korean J Acupunct 2021;38:75-99 https://doi.org/10.14406/acu.2021.010
© 2021 Korean J Acupunct