Korean Journal of Acupuncture

Table. 2.

Table. 2.

Basic characters of cold hypersensitivity of hands and feet included clinical trials

First author (year) Study design Cold hypersensitivity classification Participants N (intervention/control) Treatment Outcome measurement Main results Side effect

Intervention Control
Appiah (1997)39) RCT Hands and feet 33 (M5F11/M5F12) AcupunctureMoxibustion None ·Frequency of attacks·Overall reduction of attacks·Mean duration of the capillary flowstop ·Frequency of attacks: 1.4 day−1→0.6 day−1 (p<0.01)·Overall reduction of attacks: 63% (p=0.03)·Mean duration of the capillary flowstop reaction: 71s→24s (week12), 38s (week23) (p=0.001) None
Wang (2002)40) RCT Hands and feet 60 (M9F21/30) Warm needling Betaloc tablets ·Total efficacy rate·Nail fold microcirculation ·Total efficacy rate in intervention group: 90% (p<0.05)·Total efficacy rate in control group: 66.7%·Nail fold microcirculation improved (p<0.05)
Wang (2003)41) RCT Hands and feet 60 (M9F21/M7F23) Warm needling Metoprolol ·Total efficacy rate·Nail fold microcirculation ·Total efficacy rate in intervention group: 90.00% (p<0.05)·Total efficacy rate in control group: 66.67%·Nail fold micro circulation improved (p<0.05) None
Guo (2008)42) RCT Hands and feet 60 (M6F24/M8F22) PharmacopunctureMoxibustion Moxibustion (LI11, LI10, TE5, TE3, TE4, LI4, EX-UE9, SP6, ST36, SP9, GB39, EX-LE10) ·Total efficacy rate·Nail fold microcirculation ·Total efficacy rate in intervention group: 83.33% (p<0.05)·Total efficacy rate in control group: 56.66%·Treated group is superior to the control group in the vascular status integral and total integral of nail fold microcirculation (p<0.05) Not reported
Shen (2011)43) RCT Hands and feet 69 (M12F27/M9F21) Warm needlingFumigation Acupuncture (TE5, LI11, LI4, EX-LE10, ST36, LR3) ·Total efficacy rate ·Total efficacy rate in intervention group: 92.31% (p<0.01)·Total efficacy rate in control group: 50.00% Not reported
Yang (2013)44) RCT Hands and feet 60 (30/30) ElectroacupunctureConventional treatment of Raynaud’s disease Conventional treatment of Raynaud’s disease ·Total efficacy rate·Blood rheology, immunization series, complement determination, limb peripheral blood flow ·Total efficacy rate in intervention group: 96.67%·Total efficacy rate in control group: 83.33%·Blood rheology, immunization series, complement determination, limb peripheral blood flow improved Not reported
Ren (2015)45) RCT Hands and feet 60 (M11F19/M13F17) Acupuncture Western treatment ·Total efficacy rate ·Total efficacy rate in Acupuncture group: 90.0% (p<0.01)·Total efficacy rate in Western treatment group: 73.3% Not reported
Lee (2006)46) NRCT Hands 8 Acupuncture ·CST recovery rate ·CST recovery rate in group of distal acupuncture point: 0.86±0.92→0.88±0.09·CST recovery rate in group of proximal acupuncture point: 0.99±0.18→2.40±2.79 (p<0.05) Not reported
Schalger (2011)47) NRCT Hands and feet 26 Electroacupuncture ·Attack frequency·Severity of Raynaud attacks ·Attack frequency: 28.8±38.3→ 3.5±4.9 (p<0.001)·Severity of Raynaud attacks: VAS 6.0±2.4 → 3.0±2.8 (p=0.001) None

M : Male, F : Female, RCT : Randomized Controlled Trial, VAS : Visual Analog Scale, NRCT : Non-Randomized Controlled Trial, CST : Cold Stress Test.

Korean J Acupunct 2021;38:43-61 https://doi.org/10.14406/acu.2021.004
© 2021 Korean J Acupunct