Korean Journal of Acupuncture

Table. 1.

Table. 1.

Method and results of articles of electro-acupuncture treatment for visceral hypersensitivity

Author (year)Animal modelAnimal groupsOutcome resultsMechanism results
Li16) (2016)CVHNGAWRVR 1HSP 70 (in ST25 area).
MGn.s.n.s
EA 1 mAn.s.
EA 3 mAn.s.
Liu17) (2015)CVHNGAWRCRH (in the colon, Spinal cord, and HT)
MG↑ (in above all sites)
EA↓ (in above all sites)
Sham-EAn.s.n.s. (in above all sites)
Zhao18) (2017)CVHNGAWRMC5-HT5-HT3R5-HT4R (in the colon)
MG
EA 1 mAn.s.n.s.
EA 3 mAn.s.
Liu20) (2009)CVHNGAWR5-HT5HT3R5-HT4R (in the colon)
MG
EAn.s. n.s.
Guo21) (2013)CVHNGAWRP2X4 (in the colon and spinal cord)
MG↑ (in above all sites)
EA↓ (in above all sites)
Pinaverium bromide↓ (in above all sites)
Weng22) (2013)CVHNGAWRP2X2P2X3 (in the dorsal root ganglia)
MG
EA
Tian25) (2006)CVHNGAWR5-HT5-HT (4a)SERT (in the colon)
MG
EA
Cui26) (2005)CVHNGAWREMGNot studied.
MG
EA
Chu27) (2011)CVH(acetic acid)NGAWR5-HT3R (in the colon)
MG
EA
Sham-EAn.s.n.s.
Zhao28) (2016)CVH(NormalNGAWRMC5-HT5-HT4R (in the colon)
saline)MG
EA 1 mA
EA 3 mA
Wang10) (2015)Zymosan-induced for 3 daysNGEMGC-fos (in cortex, HT, spinal cord and colon)
MG↑ (in above all sites)
EA↓ (in above all sites)
Liu9) (2016)CPSNGAWRICCIgGIgMIL-2IL-6
MG
EA
Sham-EAn.s.n.s.n.s.n.s.n.s.n.s.
Zhou29) (2012)CPSNGAWREMGRelated to peripheral opioid pathways
MG
EA
Sham-EAn.s.n.s.
Ma30) (2009)CLDCNGThreshMCCRHSPSPR (in colon)
MGold
EA↓ ↑
Wu31) (2008)CLDCNGThreshMCSPSPRVIPVIPR (in the colon)
MGold
EA
Tegaserod↑ n.s.
Zhou32)(2017)FD model(iodo-acetamide)NGEMGSympathetic mechanisms (adrenoceptor antagonists)
MG
EA (curative)
EA (preventive)
Sham-EAn.s.

Results means significant difference of MG vs NG and treatment group(EA) vs MG.

n.s. : not significant, 5-HT : 5-hydroxytryptamine, 5-HT3R : 5-hydroxytryptamine 3 receptor, 5-HT4R : 5-hydroxytryptamine 4 receptor, AWR : abdominal withdrawal reflex, CRH : corticotropin-releasing hormone, CLDC : Constraining the limbs and distending the colorectum, CPS : chronic psychological stress, CVH : chronic visceral hypersensitivity, EMG : electromyogram, EA : electro-acupuncture, FD : functional dyspepsia, HSP : heat shock protein, HT : hypothalamus, ICC : Intersticial cells of cajal, MG : model group, MC : mast cell, NG : Normal group, P2X : purinergic receptor X, SERT : serotonin transporter, SP : substance P, SPR : substance P receptor, VIP : vasoactive intestinal polypeptide, VIPR : vasoactive intestinal polypeptide receptor, VR 1 : Vanilloid receptor subtype 1.

Korean J Acupunct 2019;36:93-103 https://doi.org/10.14406/acu.2019.006
© 2019 Korean J Acupunct