Korean Journal of Acupuncture

Table. 2.

Table. 2.

Method and results of articles of moxibustion treatment for visceral hypersensitivity

Year (Nation)Animal modelGroupsResultsMechanism
Zhou (2009)12)CVHNGAWR5-HT (in the colon)
MG
Moxa
Zhou (2009)13)CVHNGAWR5-HT (in the colon)
MG
Moxa
Zhao (2012)14)CVHNGAWRPK1PKR1 (in the spinal cord)
MG
Moxa
Zhou (2014)15)CVHNGAWRPK2PKR2 (in the colon and spinal cord.)
MG↑ (in above all sites)
Moxa↓ (in above all sites)
Li (2016)16)CVHNGAWRVR1HSP70 (in ST25 area)
MGn.s.n.s.
Moxa 43°C
Moxa 46°C
Zhao (2017)18)CVHNGAWRMC5-HT5-HT3R5-HT4R (in the colon)
MG
Moxa 43°Cn.s.
Moxa 46°C
Liu (2015)19)CVHNGAWRP2X7 (in the dorsal root ganglia)
MG
Moxa
Sham-ACn.s.n.s.
Zhou (2011)23)CVHNGAWRCRH (in hypothalamus)
MG
Moxa
Wang (2016)24)CVHNGAWRNR1NR2BPKCe (in the spinal cord)
MG
Moxa
Ro 25-6981
Zhao (2016)28)CVH(Normal saline)NGAWRMC5-HT5-HT4R (in the colon)
MG
Moxa 43°Cn.s.
Moxa 46°Cn.s.

Results means significant difference of MG vs NG and treatment group(Moxa) vs MG.

n.s. : not significant, 5-HT : 5-hydroxytryptamine, 5-HT3R : 5-hydroxytryptamine 3 receptor, 5-HT4R : 5-hydroxytryptamine 4 receptor, AWR : abdominal withdrawal reflex, CRH : corticotropin-releasing hormone, CVH : chronic visceral hypersensitivity, EMG : electro-myogram, HSP : heat shock protein, HT : hypothalamus, MG : model group, MC : mast cell, NG : Normal group, NR1 : N-methyl-D-aspartate receptor 1, P2X : purinergic receptor X, PK : prokinectin, PKC : protein kinase C, PKR : prokinectin receptor, VR 1 : Vanilloid receptor subtype 1.

Korean J Acupunct 2019;36:93-103 https://doi.org/10.14406/acu.2019.006
© 2019 Korean J Acupunct